Will & Grace: Season 10, Episode 2

10 - 2: Where in the World Is Karen Walker?

Will, Grace, and Jack are upset when they discover they've been too preoccupied with the changes in their own lives: Will teaching law at Columbia, Grace running for president of the New York Interior Designers Society, and Jack's new relationship with Estefan to even notice Karen has not been seen in days – ever since her husband found out about her affair with Malcolm.